Detail for nifedipine
Basic Information
DrugID 72
DrugName nifedipine
DrugDetail Nifedipine (brand names Adalat, Nifediac, Cordipin, Nifedical, and Procardia) is a dihydropyridine calcium channel blocker. Its main uses are as an antianginal (especially in Prinzmetal's angina) and antihypertensive, although a large number of other indications have recently been found for this agent, such as Raynaud's phenomenon, premature labor, and painful spasms of the esophagus in cancer and tetanus patients. It is also commonly used for the small subset of pulmonary hypertension patients whose symptoms respond to calcium channel blockers.

http://en.wikipedia.org/wiki/Nifedipine

Indication For the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud's phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).

http://www.drugbank.ca/drugs/DB01115

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Ketoconazole Afeltra J, Vitale RG, Mouton JW, Verweij PE. (2004) Potent synergistic in vitro interaction between nonantimicrobial membrane-active compounds and itraconazole against clinical isolates of Aspergillus fumigatus resistant to itraconazole. Antimicrob Agents Chemother. 48(4):1335-43.
Target
TargetName References EssentialGene? Link
(R)-limonene 6-monooxygenase No
4-nitrophenol 2-hydroxylase No
Adenosine A3 receptor No
Adenosine receptor A2a No
Albendazole monooxygenase No
Aromatase Yes
CAB3 No
CAB4 No
cDNA, FLJ93427, Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4(CYP3A4), transcript variant 1, mRNA No
CYPIA1 No
CYPIA2 Yes
CYPIIB6 No
CYPIIC8 No
CYPIID6 No
CYPIIIA5 No
CYPIIIA7 No
Cytochrome P450 Yes
Cytochrome P-450 No
Cytochrome P450 3A4 No
Cytochrome P450 5A1 No
Cytochrome P450 CYP3A4 No
Cytochrome P450, family 1, subfamily A, polypeptide 2 No
Cytochrome P450, family 3, subfamily A, polypeptide 5 variant No
Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma No
HK2 No
Potassium voltage-gated channel subfamily H member 2 No
Putative uncharacterized protein No
Putative uncharacterized protein DKFZp686I18188 No
Voltage-dependent calcium channel subunit alpha-2/delta-1 No
Voltage-dependent L-type calcium channel subunit alpha-1C Yes
Voltage-dependent L-type calcium channel subunit alpha-1D No
Voltage-dependent L-type calcium channel subunit alpha-1F No
Voltage-dependent L-type calcium channel subunit alpha-1S No
Voltage-dependent L-type calcium channel subunit beta-1 Yes
Voltage-dependent L-type calcium channel subunit beta-2 No
Calmodulin Yes
Potassium voltage-gated channel subfamily A member 1 Yes
Voltage-dependent T-type calcium channel subunit alpha-1H No
calcium channel L type blocker No
PathWay
PathWay Name Path Picture
pathway1
pathway10
pathway11
pathway2
pathway3
pathway4
pathway5
pathway6
pathway7
pathway8
pathway9