Detail for Disulfiram
Basic Information
DrugID 40
DrugName Disulfiram
DrugDetail Disulfiram is a drug discovered in the 1920s and used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Trade names for disulfiram in different countries are Antabuse and Antabus manufactured by Odyssey Pharmaceuticals. Disulfiram is also being studied as a treatment for cocaine dependence, as it prevents the breakdown of dopamine (a neurotransmitter whose release is stimulated by cocaine); the excess dopamine results in increased anxiety, higher blood pressure, restlessness and other unpleasant symptoms. Several studies have reported that it has anti-protozoal activity as well. Research for possible disulfiram use in cancer therapy has been announced.

http://en.wikipedia.org/wiki/Disulfiram

Indication Disulfiram is an aid in the management of selected chronic alcohol patients who want to remain in a state of enforced sobriety so that supportive and psychotherapeutic treatment may be applied to best advantage. Disulfiram is not a cure for alcoholism. When used alone, without proper motivation and supportive therapy, it is unlikely that it will have any substantive effect on the drinking pattern of the chronic alcoholic.

http://www.rxlist.com/antabuse-drug/indications-dosage.htm

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Amphotericin B Borisy A.A., Elliott P.J., Hurst N.W., Lee M.S., Lehar J., Price E.R., Serbedzija G., Zimmermann G.R., Foley M.A., Stockwell B.R., Keith C.T. (2003) Systematic discovery of multicomponent therapeutics. Proceedings of the National Academy of Sciences of the United States of America 100:7977-7982. DOI: 10.1073/pnas.1337088100.
Ketoconazole Borisy A.A., Elliott P.J., Hurst N.W., Lee M.S., Lehar J., Price E.R., Serbedzija G., Zimmermann G.R., Foley M.A., Stockwell B.R., Keith C.T. (2003) Systematic discovery of multicomponent therapeutics. Proceedings of the National Academy of Sciences of the United States of America 100:7977-7982. DOI: 10.1073/pnas.1337088100.
Target
TargetName References EssentialGene? Link
(R)-limonene 6-monooxygenase No
4-nitrophenol 2-hydroxylase No
Albendazole monooxygenase No
Aldehyde dehydrogenase Yes
Aldehyde dehydrogenase 1 family, member A1 No
Aldehyde dehydrogenase 1A1 variant No
Aldehyde dehydrogenase family 1 member A1 Yes
Aldehyde dehydrogenase, mitochondrial No
Ankyrin-like with transmembrane domains protein 1 No
CYP2E1 protein No
CYPIA2 Yes
CYPIIB6 No
CYPIIC8 No
CYPIID6 No
CYPIIIA5 No
Cytochrome P450 2A6 No
Cytochrome P450 2E1 No
Cytochrome P450, family 2, subfamily E, polypeptide 1 No
Dopamine beta-hydroxylase Yes
Mitochondrial benzodiazepine receptor No
PAM Yes
Peptidylglycine alpha-amidating monooxygenase No
Peptidyl-glycine alpha-amidating monooxygenase Yes
Putative cytochrome P450 2E1 No
Sodium/potassium-transporting ATPase alpha-1 chain No
Sodium/potassium-transporting ATPase alpha-3 chain No
Sodium/potassium-transporting ATPase subunit alpha-1 Yes
Sodium/potassium-transporting ATPase subunit alpha-2 Yes
Translocator protein No
aldehyde dehydrogenase inhibitor No
PathWay