Detail for Defensin NP-1
Basic Information
DrugID 37
DrugName Defensin NP-1
DrugDetail Defensins are small arginine rich cationic proteins found in both vertebrates and invertebrates. They have also been reported in plants. They are, and function as, host defense peptides. They are active against bacteria, fungi and many enveloped and nonenveloped viruses. They consist of 18-45 amino acids including six (in vertebrates) to eight conserved cysteine residues. Cells of the immune system contain these peptides to assist in killing phagocytized bacteria, for example in neutrophil granulocytes and almost all epithelial cells. Most defensins function by binding to the microbial cell membrane, and, once embedded, forming pore-like membrane defects that allow efflux of essential ions and nutrients. Defensin NP-1 is derived from the neutrophils of rabbits, and the sequence of NP-1 is VVCACRRALCLPRERRAGFCRIRGRIHPLCCRR.

Structure Click to see the orginal picture.
Drug Name PMIDLink Reference
Fluconazole Alcouloumre MS, Ghannoum MA, Ibrahim AS, Selsted ME, Edwards JE Jr. (1993) Fungicidal properties of defensin NP-1 and activity against Cryptococcus neoformans in vitro. Antimicrob Agents Chemother. 37(12):2628-32.