Detail for dapsone
Basic Information
DrugID 36
DrugName dapsone
DrugDetail Dapsone (diamino-diphenyl sulfone) is a medication most commonly used in combination with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae infections (leprosy). It is also second-line treatment for prophylaxis (prevention) against Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii (formerly P. carinii) in HIV patients in whom CD4 counts are below 200/mm3. Dapsone is an odorless white to creamy-white crystalline powder with a slightly bitter taste, used in combination with pyrimethamine in the treatment of malaria. Dapsone is commercially available as a gel 5% topical acne medication and is used as an acne treatment for mild to moderate acne in teens and adults. To treat acne, Dapsone is marketed as Aczone by Allergan. Oral Dapsone may also be prescribed for acne conglobata and acne fulminans, if conventional treatments for extremely severe acne, such as isotretinoin and prednisone, fail to work. Dapsone can also successfully treat other rashes like dermatitis herpetiformis.

http://en.wikipedia.org/wiki/Dapsone

Indication For the treatment and management of leprosy and dermatitis herpetiformis.

http://www.drugbank.ca/drugs/DB00250

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Clarithromycin Walzer PD, Runck J, Orr S, Foy J, Steele P, White M. (1997) Clinically used antimicrobial drugs against experimental pneumocystosis, singly and in combination: analysis of drug interactions and efficacies. Antimicrob Agents Chemother. 41(2):242-50.
Target
TargetName References EssentialGene? Link
(R)-limonene 6-monooxygenase No
4-nitrophenol 2-hydroxylase No
Albendazole monooxygenase No
CYPIIC8 No
CYPIIIA5 No
CYPIIIA7 No
Cytochrome P450 2C18 No
Dihydrofolate reductase Yes
Dihydropteroate synthase 1 No
Dihydropteroate synthase 2 No
Folic acid synthesis protein fol1 No
dihydropteroate synthase inhibitor No
PathWay
PathWay Name Path Picture
pathway