Detail for Chlorpromazine
Basic Information
DrugID 24
DrugName Chlorpromazine
DrugDetail The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine??s antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.

http://www.drugbank.ca/drugs/DB00477

http://en.wikipedia.org/wiki/Chlorpromazine

Indication For the treatment of schizophrenia, control nausea and vomiting, For relief of restlessness and apprehension before surgery, adjunct in the treatment of tetanus, control the manifestations of the manic type of manic-depressive illness.

http://www.drugbank.ca/drugs/DB00477

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Fluconazole Marchetti O., Moreillon P., Glauser M.P., Bille J., Sanglard D. (2000) Potent synergism of the combination of fluconazole and cyclosporine in Candida albicans. Antimicrobial Agents and Chemotherapy 44:2373-2381.
Ketoconazole Bengigi G., Polacheck I., Eilam Y. (1988) In vitro synergistic activity of ketoconazole with trifluoperazine and with chlorpromazine against medically important yeasts. Chemotherapy 34:96-100.
Target
TargetName References EssentialGene? Link
4-nitrophenol 2-hydroxylase No
5-HT-1A No
5-HT-2 Yes
5-HT-6 No
Adenylate cyclase type 10 No
Adenylate cyclase type 2 No
Adenylate cyclase type 4 No
Adenylate cyclase type 5 No
Albendazole monooxygenase No
ASCR No
ATP-binding cassette sub-family B member 1 No
Calmodulin Yes
Chi-1 No
CYPIA2 Yes
CYPIID6 No
D(1A) dopamine receptor Yes
D(1B) dopamine receptor No
D(2) dopamine receptor Yes
D(3) dopamine receptor Yes
Glutamate [NMDA] receptor subunit 3A No
Glutamate [NMDA] receptor subunit 3B No
G-protein coupled receptor 97 No
Histamine H1 receptor No
N(1),N(8)-bis(glutathionyl)spermidine reductase No
Potassium voltage-gated channel subfamily H member 2 No
Serum albumin No
5-hydroxytryptamine 2A receptor No
5-hydroxytryptamine 1A receptor No
Alpha-1A adrenergic receptor No
Alpha-1B adrenergic receptor No
5-HT2-receptor antagonist No
H1-receptor antagonist No
alpha2-adrenergic receptor antagonist No
dopamine D2-receptor antagonist No
muscarinic cholinergic receptor antagonist No
PathWay
PathWay Name Path Picture
Calcium signaling pathway - Homo sapiens (human)